Endocrine Abstracts

Preparations of recombinant insulin and insulin analogues are used in the treatment of insulin-dependent diabetes. Recombinant insulin that corresponds to the human sequence might be expected to cross-react extensively with insulin assays. Insulin analogues contain modifications that alter their action profiles and may therefore interact unpredictably with detection antibodies. In the differential diagnosis of hypoglycaemia it is important to be aware of the extent of the cros...

Background: Measurement of urinary cortisol is commonly used in the investigation of suspected Cushing’s Syndrome and is most often performed using immunoassay. This approach exhibits significant assay variability necessitating the use of method specific reference ranges. A reference range for cortisol nmol/L: creatinine mmol/L ratio is reported based on the results from 104 early morning urine samples collected from healthy individuals and analysed using the AutoDelfia A...